Scientist, Translational Medicine

Job Details: Scientist, Translational Medicine

Vacancy No: VN768

Employment Type: Full Time

Location: Oxford, UK

Department: Translational Medicine

Key Responsibilities

Main purpose of the job:

To design, develop and validate fit for purpose custom pharmacokinetic and immunogenicity assays used in ImmTAC programs and conduct experiments to characterize in vivo exposure, pharmacodynamic response and clinical impact.

• Design and build custom LBA and/or cell based pharmacokinetic and immunogenicity assays suitable for use in stage appropriate clinical studies.
• Assist with PK modelling and simulations using software such as Phoenix and Biomath Assess; working knowledge of R (and packages such as dplyr) would be advantageous.
• Lead technical transfer of validation ready assays to suitable third party laboratory vendors, and oversee method validation studies according to regulatory guidance and industry best practices.
• Monitor CRO assay performance and sample analysis; review and summarise PK and ADA results.
• Participate in clinical study teams as bioanalytical representative to coordinate sample collection, analysis and reporting according to established timelines.
• Design and execute exploratory bioanalytical projects; interpret data and make recommendations for next steps/future directions.
• Support preclinical studies as required to aid construct nomination and MOA investigations.
• Design and characterize custom reagents, controls and biological matrices for use in bioanalytical assays; effectively manage inventory of applicable study samples, reagents and controls.
• Keep abreast of technical advances in relevant fields through self study and attending training sessions and conferences.
• Communicate results internally in lab meetings and seminars and externally in relevant conferences.
• Operate in accordance with the company's health and safety policies.

Person Specification

• Working knowledge and understanding of bioanalytical assays for protein macromolecules with strong scientific and technical skills in method development and validation.
• A minimum of 3 years of hands on experience in the development and validation of quantitative immunoassays and immunogenicity assays for biologics.
• Experience in aseptic cell culture and cell based assay development.
• Familiar with current regulatory guidance and industry best practices for development and validation of bioanalytical methods for large molecule biologics.
• Experience in GLP and/or clinical regulatory compliance.
• Strong analytical skills and the ability to work both independently and in a team setting.
• Excellent verbal and written communication skills.

Education & Qualifications

PhD with 0 2 years of relevant professional experience in immunology, biochemistry or related discipline. Or MSc degree or BSc with equivalent, relevant experience.

Work Environment

This job operates both in a Cat 2 laboratory environment and in a professional office environment. The scientist must adhere to the company's code of practice, health and safety procedures, and rules governing the use of human tissue samples as per the company's policies.

Position Type and Expected Hours / Travel

This is a full time position. Days and hours of work are Monday through Friday, 9:00 a.m. to 5:30 p.m. (4:15 Friday).

About the Company

Immunocore (NASDAQ: IMCR) is a pioneering, commercial stage T cell receptor biotech company that develops and commercialises new generation transformative medicines for oncology, infectious diseases and autoimmune disease. Our R&D leaders are internationally recognised. We create an innovation powerhouse that answers big questions and delivers first in class biological therapies through an innovative soluble TCR platform and ImmTAX molecules.

Immunocore values its employees and embraces Science, Trust, Respect, Integrity, Diversity and Entrepreneurship (STRIDE) to foster collaboration, idea sharing and transformative change. We are proud to be an equal opportunity employer and are committed to an inclusive workplace where everyone feels valued and respected.

Equal Opportunity Employer: We encourage applications from individuals of all backgrounds, including race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status or any other characteristic protected by law.