Scientist, Phage Display, Antibody Engineering

Scientist, Phage Display, Antibody Engineering

Cambridge, United Kingdom (On site)

Job Description

We are seeking an enthusiastic Scientist to help lead the phage display platform for discovery and optimization campaigns as well as for other antibody optimization projects that support the growing pipeline of Biologics at Orion Pharma.

Responsibilities

• Provide hands on technical leadership in the laboratory for phage display campaigns used for antibody discovery and engineering projects.
• Lead optimization of the phage display techniques in accordance with the state of the art.
• Track and store phage pools during the discovery process.
• Perform and analyze NGS from antibody campaigns to identify lead clones and variants of interest.
• Give input into design and construction of synthetic phage antibody libraries used for discovery campaigns.
• Help build complementary laboratory infrastructure with the aim of automation of phage display campaigns.
• Enhance the available antibody developability analysis toolbox and incorporate it into the earliest stages of discovery.
• Guide and mentor research associates.
• Work closely together with cross functional research groups (Antibody Analytics, Antibody Expression, Antibody Purification, and Bioassays) to identify and isolate therapeutic candidates.
• Help identify and form strong alliances with external partners and CROs to ensure effective technology transfers and control strategy implementation.
• Actively contribute to cross functional internal project team discussions, ensuring research plans are aligned with the project timelines and goals.
• Understand and comply with Orion Pharma safety, quality and regulatory policies and relevant government regulations.

Qualifications

• Ph.D. in molecular biology, biochemistry, immunology or a related subject area with 3+ years of industrial experience, or an MS degree with 5+ years of industrial experience or equivalent.
• Demonstrated experience with phage display technologies for antibody discovery and engineering purposes.
• Demonstrated experience with NGS analysis.
• Demonstrated ability to construct phage display libraries.
• Expertise in antibody/protein discovery with a comprehensive understanding of the antibody structure/function relationship.
• Prior experience with CD3 based T cell engagers is preferred.
• Ability to create positive collaborations within the Research & Development team.
• Demonstrated ability to meet performance targets and project initiatives.
• Ability to assess and make decisions based on scientific data.
• Excellent oral and written communication, interpersonal, and analytical skills.

Benefits

This opportunity is to enhance phage display capacities within the Antibody Discovery team at our new location in Cambridge, UK; a unique leadership role that will help further establish and advance a core technology while building a state of the art antibody engineering powerhouse within Orion Pharma iMeds/R&D. You will work in a highly innovative R&D pipeline and enthusiastic working environment with possibilities to advance your competence and career, enjoy the exciting potential to innovate and impact future therapies, and benefit from an excellent working atmosphere based on appreciation, continuous development, and mutual trust.

Location

• The Bennett building B930 Babraham Research Campus, Cambridge, CB22 3AT, GB (On site)