Research Leader (In-vitro Pharmacology, Exploratory Sciences), London

Research Leader (In vitro Pharmacology, Exploratory Sciences), London The employer is Clear and nothing is A concern, but one or two parts are Worth checking or Not known. It describes the role and the employer, not your chances.

Role Clear

This role appears to map to SOC 2112 (Biological scientists), an eligible Skilled Worker occupation at RQF 6 or above under the rules in force on 8 November 2026.

Isomorphic Labs Limited holds a Skilled Worker licence with an A rating on our register, last checked 7 November 2026.

The advert does not mention sponsorship.

Checked 8 Nov 2026. General information about this role, its employer and the published rules, not advice about anyone's situation. Immigration rules change; check GOV.UK. For advice, use a regulated adviser: find one at or a solicitor at

Evidence for this role How evidence works Some evidence

The employer is Clear and nothing is A concern, but one or two parts are Worth checking or Not known. It describes the role and the employer, not your chances.

Role Clear

This role appears to map to SOC 2112 (Biological scientists), an eligible Skilled Worker occupation at RQF 6 or above under the rules in force on 8 November 2026.

SOC 2112 RQF _6_PLUS GOV.UK Pay Not known

The advert does not state a salary.

Employer Clear

Isomorphic Labs Limited holds a Skilled Worker licence with an A rating on our register, last checked 7 November 2026.

Register Advert Not known

The advert does not mention sponsorship.

Advert

Checked 8 Nov 2026. General information about this role, its employer and the published rules, not advice about anyone's situation. Immigration rules change; check GOV.UK. For advice, use a regulated adviser: find one at or a solicitor at

The advert has no salary. What pay do the rules need?

The advert doesn't state a salary 1 , so ask the employer what the role pays before you apply.

• 1 Research Leader (In vitro Pharmacology, Exploratory Sciences), London Isomorphic Labs job advert

In your full answer What other London adverts pay

From this page's records

The advert has no salary. What pay do the rules need?

The advert doesn't state a salary 1 , so ask the employer what the role pays before you apply.

Some evidence In your full answer What other London adverts pay Free with an account

About the role Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life changing medicines with an ambition to solve all disease.

The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery.

Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring and collaborative culture.

The world we want tomorrow is the one we're building today. It starts with the culture at this company. It starts with you.

About Iso Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed.

Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI's powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world's most devastating diseases.

We have built a world leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting edge capabilities to advance rational drug design.

Every day, and with each new breakthrough, we're getting closer to the promise of digital biology, and achieving our ambitious mission to one day solve all disease with the help of AI.

About the Exploratory Sciences Team You will be joining the expanding "Exploratory Sciences" team, focused on tackling proteins which are critical for disease biology, but have been traditionally considered intractable.

We are a multidisciplinary team within the Drug Design and Medical Research function at Isomorphic Labs. We work where machine learning, chemical biology and drug discovery meet, applying the Isomorphic Labs platform to some of the hardest problems in the field.

Our work goes beyond individual targets. We explore emerging therapeutic modalities, molecular glues and peptides to modalities that don't have a playbook yet. We also design the data generation strategies that make these modalities workable for AI driven design. The experiments we run don't just move drug discovery programmes forward - They shape the models that power Iso's drug design engine.

We're as comfortable in silico as we are at the bench. Our scientists build and test hypotheses computationally, use LLM based agentic workflows in their daily science, and work alongside ML researchers and engineers on Platform builds. We work closely with teams across Isomorphic Labs, so ideas move quickly from model to real world experiments and back again, keeping the goal of drug discovery and development front and centre.

Above all, we're curious and ambitious, and we care about growth. We put continuous learning and development first, because we're building the next generation of drug discovery scientists. If you want to help define what drug discovery looks like next, you'll fit right in.

Your impact We're looking for an accomplished in vitro pharmacology leader to build and lead a team of biologists in Exploratory Sciences, and to shape how Iso tests and validates new therapeutic modalities.

You'll own the experimental pharmacology strategy across our exploratory portfolio. You'll decide which questions are worth asking, which assays and cascades will answer them, and what "decision quality" means for modalities that don't have an established playbook yet. Your judgement will directly shape which ideas move forward.

You'll make the data count twice. Every experiment your team designs should move a programme forward and also make our models smarter. You'll work out if the platform has a blind spot, then innovate on assays to generate the datasets that fill it. The result is a closer loop between in silico predictions and experimental results.

You'll set the standard for how modern biologists work. You'll lead by example in using LLM agentic workflows and in silico hypothesis building, and help your team make them a natural part of daily science. Working as an equal partner with ML, engineering and computational colleagues, you'll help shape the tools your team relies on.

You'll mentor a team of research investigators who are experienced bench scientists and fluent in applying creative ai first approaches to drug discovery , and help them become the leaders Exploratory Sciences needs as it continues to expand

Ready to elevate your scientific career? Isomorphic Labs offers ambitious scientists a unique environment to tackle stimulating challenges, pushing your boundaries and accelerating your personal and professional growth. If you are a skilled and ambitious scientific leader looking to take the next step in your career, Isomorphic Labs will provide you with that amazing opportunity unlike any other.

What you will do: Modality Strategy & Target Prosecution:

• Set the in vitro pharmacology vision for exploratory programmes across TPD, molecular glues, peptides and next generation modalities.
• Assess the tractability of new modalities against challenging targets and set rigorous go/no go criteria.
• Turn therapeutic concepts and TPPs into rigorous screening cascades for internal and partnered programmes.
• Lead the design of biochemical, biophysical (e.g. SPR/GCI, nanoDSF, Spectral Shift, MST) and bespoke screening cascades for novel modalities.
• Develop quantitative assays covering binding kinetics, ternary complexes, degradation and functional pathway readouts (e.g. HiBiT, NanoBRET, TR-FRET).
• Work closely with medicinal chemistry and DMPK to drive SAR and compound de risking.
• Set data quality, ontology and QC standards so that internal and CRO data are ML ready from the start.

AI, Agentic Workflows & Platform Builds:

• Champion the use and co development of LLM agentic workflows to speed up hypothesis generation, experimental design and data synthesis.
• Work with ML and engineering teams on Platform builds, contributing biological domain expertise to model and workflow design.
• Test in silico hypotheses rigorously in the wet lab and build plans that move programmes forward and fill systematic gaps in our models.
• Give stakeholders and collaborative teams critical biological input to guide generative design for new modalities.

Scientific Leadership & External Partnerships:

• Lead a team of Research and Senior Research Investigators . click apply for full job details