Postdoctoral Scientist in Structural Biology

Jobs in Structural Biology and Related Fields Postdoctoral Scientist in Structural Biology

University of Oxford, Oxford, United Kingdom

Postdoctoral Scientist in Structural Biology

Weatherall Institute of Molecular Medicine

University of Oxford

Applications are invited for a postdoctoral position to discover and develop inhibitors of oncogenic proteins for cancer treatment. The post is available for 3 years, funded by the Medical Research Council.

The aim of the work is to discover small molecule drugs that inhibit protein protein interactions involving transcription factor multi protein complexes. The approach will involve novel strategies using single domain antibody fragments and peptides as tools for the identification of drug like molecules for hit to lead development and assay development for characterization and target validation.

The programme involves structural determination of protein complexes together with screening and characterization of small molecule inhibitors of protein protein interactions. In particular, the project will use the structure of single antibody domains as templates for drug lead development.

Candidates must have a PhD in structural biology, experience with recombinant protein production purifications, with solving structures using X ray diffraction and analyzing protein interactions using biophysical techniques. Experience with mammalian and yeast culture would be an advantage.

Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application.

The closing date for this position is noon on Thursday 21 November 2013.

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