Postdoctoral Scientist - Neurobiology - Dr Anne Bertolotti - LMB 2792

MRC Laboratory Of Molecular Biology, UKRI

Postdoctoral Scientist

Salary £42,694 per annum

Fixed term, 3 years

MRC Laboratory of Molecular Biology, Cambridge, UK

Job Overview

The position is for a Postdoctoral Scientist with expertise on cryoEM and/or protein biochemistry. You will be responsible for expressing, purifying phosphatases and kinases and solving their structures using a combination of approaches, primarily cryoEM and/or crystallography, with the support of LMB facilities. You may also develop new inhibitors and conduct functional studies.

Dr Anne Bertolotti's pioneering research programme focuses on innovative approaches to boost stress signaling pathways to increase cellular resilience and protect from diverse diseases including neurodegenerative diseases. We have developed approaches to inhibit or activate phosphatases or kinases of the integrated stress response and are progressing towards a structural understanding of these important enzymes (Tsaytler et al., 2011, Science, 332, 91-4; Das et al., 2015, Science, 348, 239-242; Carrara, M., Sigurdardottir, A., & Bertolotti, A. 2017, Nat Struct Mol Biol; Krzyzosiak, A., Sigurdardottir, A. et al., A. 2018, Cell; Szaruga M, et al., Nat Commun, 2023. 8;14(1):5535; Fatalska A., Hodgson G, et al., Mol Cell. 2024; Miguel, C. D. et al. Science eadw). The small molecules discovered by the group are currently tested in clinical trials for neurodegenerative diseases. You will provide fundamental structural and mechanistic insights on these important enzymes and expand on the next generation of inhibitors.

You will join a strong inter-disciplinary team at the LMB, which has broad expertise extending from biochemistry, structural, chemical, molecular and cell biology through to transgenic animal models of degenerative diseases. The team also has an excellent record of innovative basic research leading to applications in medicine.

Responsibilities

• Express, purify phosphatases and kinases and solve their structures using cryoEM and/or crystallography.
• Develop new inhibitors and conduct functional studies.
• Provide structural and mechanistic insights on target enzymes and expand on next-generation inhibitors.

Qualifications

• PhD in biochemistry or structural biology, or completing the degree within six months of applying.
• Relevant experience with at least one impactful and original publication.
• Interest in signaling enzymes desirable.
• Ambitious, creative and fearless with a commitment to explore the unknown.

Benefits

The LMB provides on-site parking, cycle enclosures, and excellent public transport links. There is a staff restaurant with roof terrace and access to a campus nursery and sports and social facilities. Employees are eligible to join a defined benefit pension scheme, receive 40.5 days of holiday per annum (including bank holidays and privilege days), and benefit from a generous employee discount scheme. Training and development opportunities, including support towards role-related qualifications, are available. For more information, see Benefits of working at UKRI .

The LMB is a world class research institute within UK Research and Innovation (UKRI). More information can be found at UKRI and MRC LMB .

This role qualifies for endorsement by UKRI for a UK Global Talent Visa. Immigration costs (visa and health surcharge) can be reclaimed from UKRI after taking up the post (terms and conditions apply).

Closing date: 22 March 2026

Final appointments will be subject to a pre employment screening.

Equality and Diversity

We actively support equality, diversity and inclusion in all our activities, processes and culture. We encourage applications from all sections of society. The LMB particularly welcomes women, minority ethnic and disabled candidates to apply for this vacancy as they are currently under represented. We are a disability inclusive employer and encourage disabled people to apply. For information about the application process and any adjustments you may require, contact emailprotected .