Postdoctoral Research Scientist

Job Info

• Job Category Science
• Apply Before 06/07/2026, 10:55 PM
• Job Identification 2317
• Posting Date 05/06/2026, 02:18 PM
• Job Shift Day
• Hours Full Time

Job Description

MRC Postdoctoral Research Scientist in Immunometabolism (LMS 2317)

Salary: £42,694 plus London allowances £5,560 per annum

Additional allowances comprise a £1,000 lump sum Settlement Allowance plus a yearly Training Allowance of £850 in the first year, paid in monthly instalments. The Training Allowance increases to £1,300 in year two, and £1,800 in the third year.

Fixed Term 3-years Full time Location: Hammersmith, London Closing Date: 7 June 2026

Overall purpose:

The Endocrine Signalling in Inflammation group investigates how gut hormones and related peptides modulate systemic inflammation via the gut-brain-immune axis. Leveraging the MRC LMS core facilities, we combine in vivo models, multi-scale phenotyping, and omics to map the pathways governing organ crosstalk and translate them into new strategies for managing chronic conditions, with a current focus on diseases driven by immunometabolic dysfunction.

We are seeking a talented Postdoctoral Scientist with expertise in Physiology, Immunology, or Metabolism to join our team. As a key member, you will lead efforts to map the specific immune pathways through which these endocrine signals coordinate systemic inflammatory responses. Specifically, you will couple immunological techniques with metabolic modelling in transgenic mouse models to decipher how gut hormones and related peptides regulate peripheral immunity under immunometabolic stress.

Background in Physiology, Metabolism, or Immunology is required

Extensive experience in designing and executing complex, longitudinal in vivo mouse models (e.g. dietary or inflammatory studies using transgenic models) is required

Proficiency in cellular and molecular assays (e.g. cell/tissue culture, tissue-clearing/imaging, high-dimensional flow/spectral cytometry) to define signalling pathways is essential

The ability to adapt across disciplines and the drive to establish novel techniques is essential

Main Responsibilities:

To lead in vivo research projects investigating how gut hormones and related peptides modulate inflammation via the gut-brain-immune axis

To collaborate closely with other members of the team on various projects

To prepare work for publication and grant submissions

To present at seminars and conferences as necessary

To co-supervise MSc and PhD students

To contribute to the smooth running of the Group's/Unit's laboratories and facilities with other scientists, clinicians, technicians and students within the laboratories

To comply with the Institute, College, Division, and Unit safety practices and to attend courses on safety when appropriate

Any other duties as may be deemed reasonable by Head of group as well as Head of Division

Person requirements

Education / Qualifications / Training required:

PhD (or equivalent) in Physiology, Immunology, Pharmacology, or a closely related Biomedical Science discipline

Previous work experience required:

Proven track record of leading independent research projects from hypothesis generation to data interpretation

Extensive experience designing and executing complex, longitudinal in vivo mouse models (e.g., transgenic, dietary, or inflammatory models)

Demonstrated record of high-quality research through first-author publications in peer-reviewed journals

Experience collaborating effectively within multidisciplinary teams to achieve shared research objectives

Knowledge and experience:

A theoretical understanding of endocrine signalling, immunometabolism, and/or neural regulation of physiology

Competency in mouse handling, colony management, and standard dosing routes

Specific experience in mouse studies of inflammation/ immunology (e.g. high-dimensional flow/spectral cytometry or microscopy for immune cells) or in vivo metabolism (e.g. dietary models, metabolic phenotyping techniques)

Excellent written and oral communication skills in English, with a proven ability to prepare manuscripts for publication and present scientific data effectively at seminars

Specific experience in in vitro mouse or human immune

Personal Skills / Behaviours / Qualities:

Ability to conduct reproducible research

Ability to conduct a detailed review of recent literature

Ability to develop and apply new concepts

Creative approach to problem-solving

A keen interest in learning new skills

Excellent verbal communication skills in English and the ability to deal with a wide range of people

Ability to motivate others to produce a high standard of work

Ability to organise own work with minimal supervision

Ability to prioritise own work in response to deadlines

Advanced computer skills, including word-processing, spreadsheets and the internet

Willingness to work as part of a team and to be open-minded and cooperative

Flexible attitude towards work

Discipline and regard for confidentiality and security at all times

Willingness to undertake any necessary training for the role