Post-doctoral position

Jobs in Structural Biology and Related Fields Post-doctoral position

MRC Laboratory of Molecular Biology, Cambridge, UK, United Kingdom

MRC Laboratory of Molecular Biology, Cambridge, UK

Post-doctoral position

We seek to appoint a postdoctoral researcher to the Division of Structural Studies to undertake protein crystallographic analysis of the anaphase promoting complex (APC/C) and its subunits. This is an Investigator Scientist position funded by Cancer Research UK for 3 years and is located at the MRC Laboratory of Molecular Biology in Cambridge, UK within the group of David Barford.

The Investigator Scientist will join a team investigating the structure and mechanism of the anaphase promoting complex (APC/C), a large macro-molecular assembly that regulates progression through the cell cycle. The project will focus on crystal structure determination of the whole APC/C and APC/C subunits and sub-complexes. This project extends our existing 11 Å resolution structure determined using single particle electron microscopy and takes advantage of our recombinant over expression system for reconstituting APC/C (da Fonseca et al., (2011) and Schreiber et al., (2011 . The project would suit a highly motivated and committed scientist interested in molecular mechanisms of the cell cycle, cancer biology and structural biology.

The successful applicant will hold at least a PhD (or equivalent) in a biological/physical science. Experience with protein crystallography is essential and experience with protein crystallisation and purification would be an advantage.

The post is available from 1 st October 2013 (or earlier). The starting salary will be set within £26,282 to £31,686. However, the full salary range for a position of this type is from £26,282 - £37,040.