Senior Postdoctoral Fellow/Postdoctoral Fellow - Somatic Genomics Programme

Senior Postdoctoral Fellow/Postdoctoral Fellow - Somatic Genomics Programme

Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity's greatest challenges.

This position offers a unique opportunity to address fundamental questions in human somatic evolution and its consequences for disease and inheritance. The role spans multiple ongoing projects investigating (i) the dynamics of somatic evolution in normal and precancerous tissues, and (ii) the impact of environmental and clinical exposures including chemotherapy on mutational processes across tissues and their potential transmission to the next generation.

What you'll be doing:

• Designing and delivering an original research project aligned with ongoing work on somatic evolution, contributing new ideas and helping shape future research directions.
• Applying and extending state of the art computational and/or experimental approaches to analyse large scale sequencing datasets and address complex biological questions.
• Working at the interface of computational biology, genomics and evolutionary modeling, leveraging large scale sequencing datasets (including whole genome and duplex sequencing) to uncover patterns of mutation accumulation, clonal dynamics and selection.
• Taking advantage of opportunities to develop and apply novel analytical frameworks, integrating multi omic data (DNA, RNA and epigenomics) to generate new biological insights.
• Contributing to a collaborative and inclusive research environment through knowledge sharing, teamwork and engagement with the wider scientific community.

You will have a computational or quantitative background and experience contributing to research. You are interested in developing your independence and shaping research directions, while working within a collaborative and supportive team environment.

You enjoy working with others, sharing ideas and learning new approaches, and are motivated by contributing to research that improves our understanding of human health and disease. You are keen to continue developing your skills and expertise, with support and mentorship.

Qualifications

• PhD in a relevant subject area, including Cancer Genomics, Biological Sciences, Medicine, Computational Biology, Bioinformatics, Statistics, or a related quantitative discipline, or on track to be awarded within 6 months of starting the role.
• Proven ability to deliver research projects
• A track record of demonstrating research excellence and expertise in your area of research
• Ability to analyse and interpret data with strong quantitative/computational skills
• Experience in programming and data analysis (e.g. Python, R, or similar)
• Previous work experience in a molecular biology laboratory
• Experience with core molecular biology techniques, including sample preparation, RT, qPCR and RNA/DNA extraction
• Proven ability to develop and maintain effective working relationships with a wide range of backgrounds, experience and expertise
• Foster an inclusive culture where all can thrive and diversity is celebrated
• Ability to work with others in a collegiate and collaborative environment
• Ability to effectively communicate ideas and results and present orally to groups
• Commitment to personal development and updating of knowledge and skills
• Ability to prioritise, multi task and work independently
• Detail oriented, strong organisational and problem solving skills

Additional Skills for Senior Postdoctoral Fellow

• Proven ability to lead and deliver research projects, including evidence of taking projects from conception through to publication
• A demonstrable track record of research excellence, demonstrated through high quality publications, preprints, or equivalent research outputs
• Expertise in analytical and quantitative skills, with demonstrated ability to analyse, interpret, and integrate complex large scale datasets
• Demonstrated experience in computational biology/genomics, including analysis of DNA sequencing data (e.g. whole genome sequencing); experience with RNA or methylation data is advantageous
• Proficiency in programming and data analysis (e.g. Python, R, or similar), and experience working in high performance or large scale computing environment
• Excellent influencing skills to engage internal and external stakeholders from a variety of backgrounds
• Demonstrated mentorship, supervision and leadership abilities

Salary per annum (dependent upon your skills and experience)

£38,570-£49,893

Application Process

Please apply with your CV and a cover letter outlining how you meet the criteria set out above.

Closing Date

6th May 2026

Equality, Diversity and Inclusion

We aim to attract, recruit, retain and develop talent from the widest possible talent pool, thereby gaining insight and access to different markets to generate a greater impact on the world. We have a supportive culture with the following staff networks, LGBTQ+, Parents and Carers, Disability and Race Equity to bring people together to share experiences, offer specific support and development opportunities and raise awareness. The networks are also a place for allies to provide support to others.

We want our people to be whoever they want to be because we believe people who bring their best selves to work, do their best work. That's why we're committed to creating a truly inclusive culture at Sanger Institute. We will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.