Scientist, Macrophage & Myeloid Biology

Your mission

Engitix Therapeutics is a pioneering biotechnology company unlocking extracellular matrix (ECM) biology to develop transformative therapeutics for fibrosis and oncology. By combining proprietary human ECM-based platforms with advanced cellular models, we are uncovering novel biology at the immune stromal interface and translating these insights into innovative drug discovery programmes.

We are seeking a talented Scientist with expertise in macrophage and myeloid biology to join our Discovery Biology team.

Key Responsibilities

• Establish scalable workflows for processing human blood and leukopak samples, including PBMC isolation and generation of primary human macrophages.
• Develop, optimise, and execute functional assays using primary and engineered immune cells, with a particular focus on macrophages and other myeloid cell populations.
• Perform multi-colour and high-parameter flow cytometry for immune cell phenotyping and functional characterisation.
• Design and execute macrophage activation, phagocytosis, cytokine secretion, and co culture assays to investigate target biology and therapeutic activity.
• Develop and apply approaches to understand macrophage heterogeneity and function within disease relevant microenvironments.
• Support the development of immune stromal and ECM based cellular models for target discovery and therapeutic screening.
• Analyse, interpret, and communicate experimental findings to multidisciplinary project teams.
• Contribute to the development of new macrophage and myeloid biology capabilities through implementation of innovative technologies, cellular models, and experimental approaches.
• Maintain accurate laboratory records and support safe and efficient laboratory operations.

Your profile Essential

• Strong background in macrophage and myeloid cell biology.
• Significant hands on experience handling human blood samples, leukopak processing, PBMC isolation, and immune cell culture.
• Experience deriving, characterising, and functionally evaluating primary human macrophages.
• Strong experience with multi colour and/or high parameter flow cytometry, including immune phenotyping and data analysis.
• Experience developing and executing immune cell based functional assays.
• Strong experimental, analytical, and problem solving skills.
• Excellent communication skills and ability to work effectively within multidisciplinary teams.

Desirable

• Experience in immuno oncology, fibrosis, inflammation, or tissue remodelling research.
• Experience with antibody based therapeutics or immune modulating agents.
• Experience with stromal biology, extracellular matrix biology, or immune stromal co culture systems.
• Experience with molecular biology techniques such as qPCR, RNA analysis, CRISPR based perturbation, or gene knockdown approaches.
• Previous experience in a biotechnology or pharmaceutical research environment.

Qualifications

• PhD in Immunology, Cell Biology, Biomedical Sciences, Cancer Biology, or a related discipline.
• Typically 2-4 years of relevant postdoctoral and/or industry experience.
• Demonstrated ability to independently design, execute, troubleshoot, and interpret experiments.
• Passion for hands on laboratory research and scientific discovery.

Why us?

• Work at the forefront of immune stromal biology in fibrosis and oncology.
• Contribute directly to target discovery and early drug development programmes.
• Applycutting-edgetechnologies to answer important biological questions with therapeutic relevance.
• Collaborate within a highly multidisciplinaryinternal and externalteamsand innovative research environment.
• Gain broad exposure to drug discovery whilemaintainingstrong scientific and technical ownership.
• Help deliver transformative therapies for patients with significant unmet medical need.