Principal Scientist, Genomic Translational Research

Principal Scientist, Genomic Translational Research

We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.

We are seeking a highly motivated Principal Scientist with hands on expertise in molecular biology in the context of immuno oncology to join the Oncology Translational Research team within GSK Oncology TA. The successful candidate will work as part of a team that evaluates patient derived organoids through cutting edge cellular, genomic and molecular techniques, and partners with AI/ML and analytics experts to integrate data from these multimodal approaches to generate clinical insights. The goal of this is to improve cancer patient risk stratification, identify clinical biomarkers and predict future targeted and/or immuno therapy susceptibilities.

In this role you will:

• Create protocols and perform the sample processing for genomic experiments (e.g. RNAseq, WES, scRNAseq).
• Prepare samples and libraries for sequencing.
• Run flow cytometry and FACS sorting experiments.
• Develop immunogenicity assays for product validation.
• Offer technical expertise and support to other team members, helping them troubleshoot and optimize their experimental protocols. Solve technical issues operate as part of a cross functional project team.
• Collaborate with King's College London scientists within the GSK KCL Translational Oncology Research Hub, an exclusive research collaboration between GSK and the Comprehensive Cancer Centre at KCL.

Basic Qualifications & Skills

• PhD (or equivalent experience) in Cancer Biology, Genomics, Immunology, or related field, with extensive experience in cancer genomics.
• Expertise with NGS, flow cytometry, single cell RNA sequencing and library preparation.
• Strong background in developing and applying cutting edge genomic technologies to study cancer biology.
• Strong understanding of immunology and cancer biology, including T cell biology and the molecular mechanisms underlying tumorigenesis and cancer progression.
• Ability to communicate with team members from different backgrounds by training/discipline, as well as senior members of the GSK stakeholders/research partner units.
• Ability to deliver high quality, consistent results in a timely fashion with a positive can do and result oriented attitude.

Preferred Qualifications & Skills

• A track record of scientific publication.
• Experience in collaboration with biopharma.
• Strong strategic thinking and problem solving skills, with the ability to navigate complex scientific and business challenges.
• Experience in analysis of major next generation sequencing (sc TCR) techniques and generation of insights from such data.

Closing Date for Applications

9th March 2026

Adjustments to the Recruitment Process

Please note, if you require any adjustments during our recruitment process to assist you in demonstrating your strengths and capabilities, contact us at . You can also request a call.

Equal Opportunity Employer

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.