Principal Scientist, Cell Culture Patient Derived Organoids

Job description

Site Name: UK - Hertfordshire - Stevenage

Posted Date: Jan

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Principal Scientist, Cell Culture Patient Derived Organoids

We are looking for a highly motivated scientist with experience in organoid culture and oncology cellular biology to join the Oncology Translational Research team within GSK Oncology Therapeutic Area (TA). The Oncology Translational Research team will partner with Oncology TA team members increase clinical translatability and to contribute to preclinical development programmes within GSK Oncology TA. The successful candidate will work as part of a team that, by exploiting patient-derived organoids, is developing and implementing cutting-edge cellular, genomic and molecular techniques with a multimodality analytic approach, plus machine learning models to improve cancer patient risk stratification as well as to predict future targeted and/or immuno-therapy susceptibilities.

We value curiosity, clear thinking, practical problem solving and a focus on impact for patients. This role offers growth, the chance to shape new technologies, and a direct contribution to GSK's mission of uniting science, technology and talent to get ahead of disease together.

In this role you will

• Be involved in the expansion and culture patient-derived organoids independently or in co-culture with other cell types, such as immune cells or fibroblasts.

• Perform quality control procedures on patient-derived organoids, including evaluating cell density, proliferation rates, and cytotoxicity, as well as carrying out cell culture and expansion.

• Conduct flow cytometry analyses on organoids and other cell types.

• Collect and report experimental data to the laboratory head.

• Collaborate and cooperate with scientists from King's College London within the GSK-KCL Translational partnership.

Why you?

Basic Qualifications & Skills:

• PhD in Cell Biology/Oncology or related, OR a Masters with equivalent experience, plus a multidisciplinary mix of training/expertise in Oncology and Cancer cell biology.

• Significant experience in cell culture techniques (patient-derived organoids, immune cells, cancer associated fibroblasts), cytotoxicity analysis.

• Flow cytometry experience (multi-colour panel preparation, antibodies titration, cell staining, FlowJo analysis)

• Ability to deliver high quality, consistent results in a timely fashion with a positive can-do and result oriented attitude

Preferred Qualifications & Skills:

Please note the following skills are not necessary, just preferred, if you do not have them, please still apply:

• Background of immunology

• A track record of scientific publication

• Experience in collaboration with biopharma

• Experience in laboratory automation.

Closing Date for Applications 13th February 2026

Please take a copy of the Job Description, as this will not be available post closure of the advert.

When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people's lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients' needs and have the highest probability of success. We're uniting science, technology, and talent to get ahead of disease together.

Find out more: Our approach to R&D.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

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