Associate Scientist / Research Scientist - Upstream Process Sciences

Associate Scientist / Research Scientist - Upstream Process Sciences

Slough, United Kingdom

Job Description About the Role

To strengthen our Drug Substance Process Sciences team, we are seeking atalented and motivatedAssociate Scientist / Research Scientisttosupport upstream process development for biologics.

You will contribute to early-stage process development, processoptimisation, technology transfer, and manufacturing support activities.Working within a multidisciplinary team, you will help develop scalablemammalian cell culture processes, perform process characterisation andtroubleshooting studies, and support the delivery of innovative proteintherapeutics.

This is a laboratory-based role offering exposure to advanced cellculture technologies, high-throughput platforms, and bioreactor systems rangingfrom microscale to pilot scale.

Your Activities Process Development & Laboratory Operations

• Design, plan, and execute upstream processdevelopment studies with minimal supervision.
• Apply QbD and DoE approaches to processoptimisation and characterisation.
• Perform mammalian cell culture experiments usingshake flasks, Ambr systems, and laboratory-scale bioreactors.
• Support scale-up, scalability assessments, processtroubleshooting, and technology transfer activities.
• Utilise automation and high-throughput technologiesto improve workflow efficiency.
• Contribute to evaluation of emerging technologiesand platform improvements.

Data Analysis & Scientific Communication

• Analyse and interpret experimental data usingappropriate statistical approaches.
• Generate accurate, high-quality scientific data anddocumentation.
• Prepare technical reports, protocols,presentations, and project summaries.
• Communicate findings and recommendations to projectteams and stakeholders.
• Collaborate with Cell Line Development, AnalyticalSciences, Downstream Development, Manufacturing and external partners.
• Represent Upstream Process Sciences incross-functional project teams.
• Maintain accurate laboratory records and electroniclaboratory notebooks.
• Ensure compliance with HSE, GMP/GSP, qualitysystems, and data integrity requirements.
• Participate in continuous improvement initiativesand laboratory best practices.

Requirements

• MSc in Biotechnology, Biochemical Engineering,Chemical Engineering, Molecular Biology, Cell Biology, Bioprocess Engineering,or related discipline. or BSc with relevant industrial experience.

Technical Skills & Experience

• Experience in mammalian cell culture and biologicsprocess development.
• Hands-on experience with CHO cell culture and therapeutic protein production.
• Experience operating Ambr and/or laboratory-scalebioreactor systems.
• Knowledge of cell culture scale-up principles andprocess characterisation.
• Experience applying DoE and statistical dataanalysis tools.
• Strong scientific problem-solving andtroubleshooting skills.
• Experience with automation, digital tools, and datamanagement systems.
• Understanding of GMP, data integrity, and qualityrequirements.

Advantageous

• Perfusion or ATF process experience.
• Technology transfer and manufacturing supportexperience.
• Exposure to downstream processing and integratedprocess development.