Clinical Research Fellow

Our mission is to maximise and advocate for the holistic health of all children, young people and the adults they will become, through world-class research, education and public engagement. The UCL GOS ICH, together with its clinical partner Great Ormond Street Hospital for Children, forms the largest concentration of children's health research outside North America. The 2024-29 GOS ICH strategy focuses on its five scientific programmes. GOS ICH's activities include active engagement with children and families, to ensure that our work is relevant and appropriate to their needs. GOS ICH generates the funding for our research by setting out our proposals in high quality applications to public, charitable and industrial funding bodies and disseminates the results of our research by publication in the medical and scientific literature, to clinicians, policy makers and the wider public. The Institute offers world-class education and training across a wide range of teaching and life learning programmes which address the needs of students and professional groups who are interested in and undertaking work relevant to child health. GOS ICH holds an Athena SWAN Charter Gold Award.

About the role

An opportunity has become available to join a clinical team undertaking Phase I clinical evaluation of novel CAR-T cell therapeutics in children with malignant brain tumours, which will be conducted at Great Ormond Street Hospital in partnership with the UCL Institute of Child Health. The post holder will be a clinician with significant experience in the management of children with cancer and will have an academic and clinical interest in the evaluation of experimental therapeutics within clinical trials. The appointee will have responsibility for recruitment to and management of patients and clinical data collection from the trial as well as supporting the patient management and data collection in other phase I studies. The appointee will fall under the overall line management of Professors Darren Hargrave (clinical PI) and John Anderson (scientific CI). This salary offered on this post is £65,048 - £73,992 per annum, nodal point 4-5 on the resident doctor pay scale and is funded until 28/02/2028 in the first instance.

About you

Main purpose summarised as follows:

• Responsible for day to day running of Phase I clinical trial of CARTUNE clinical trial in paediatric brain tumour patients.
• Clinical data collection and quality analysis of CARTUNE trial patients.
• Liaison with manufacturing and laboratory teams for organisation of trial related procedures.
• Working with sponsor and manufacturing teams to coordinate regulatory submissions for parallel trials.

Duties and responsibilities:

• To be responsible for the organisation and co ordination of patients enrolled on CARTUNE clinical trial.
• To contribute to the management of trial patients on related Phase I studies at Great Ormond Street Hospital.
• To problem solve logistical issues related to day to day management of patients undergoing complex investigation cell therapies.
• To ensure that the trial operates in accordance with current policies, relevant regulatory requirements and with due regard to underpinning scientific and ethical principles; to ensure compliance with University, Hospital, HTA regulations.
• To link with the preclinical team and development and regulatory submissions for other experimental therapeutics cell therapy paediatric trials.
• To participate in teaching and training of junior or new members of the trials team.
• To coordinate the opening of CARTUNE and other cell therapy trials at satellite clinical sites.
• To contribute to the drafting and submission of meeting abstracts, posters and research manuscripts.

The ideal candidate for this post will be a medical doctor with specialist training in paediatrics and paediatric oncology, and interest in academic clinical trials and translational medicine. Applications from candidates interested in registering for research degrees are particularly welcome.

What we offer

• 41 Days holiday (including 27 days annual leave, 8 bank holidays and 6 closure days)
• Defined benefit career average revalued earnings pension scheme (CARE)
• Cycle to work scheme and season ticket loan
• On site nursery
• On site gym
• Enhanced maternity, paternity and adoption pay
• Employee assistance programme: Staff Support Service
• Discounted medical insurance

Our commitment to Equality, Diversity and Inclusion

As London's Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world's talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong. We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL's workforce. These include people from Black, Asian and ethnic minority backgrounds; disabled people; LGBTQI+ people; and for our Grade 9 and 10 roles, women. You can read more about our commitment to Equality, Diversity and Inclusion here: